NOBEL PRIZE 2022 | Nobel prize goes to pioneers of Lego-like “click chemistry”

October 5, 2022 , 10:52 PM

By Johan Ahlander, Ludwig Burger and Marie Mannes

STOCKHOLM, Oct 5 (Reuters) – Scientists Carolyn Bertozzi, Morten Meldal and Barry Sharpless won the 2022 Nobel Prize in Chemistry on Wednesday for discovering reactions that let molecules snap together to create new compounds and that offer insight into cell biology.

The field of click chemistry and bioorthogonal chemistry has been harnessed to improve the targeting of cancer pharmaceuticals now being tested in clinical trials, along with a host of health, agricultural and industrial applications.

“Combining simple chemical building blocks makes it possible to create an almost endless variety of molecules,” the award-giving body said in a statement, adding that “sometimes simple answers are the best”.

Danish winner Medal described click chemistry as a way to build complex structures and link them as if they were pieces of Lego, the plastic construction toy.

The technology is employed globally to learn more about cells and track biological processes. It also allows assembly in the lab of stable molecules without creating undesirable by-products that had hobbled older methods.

Sharpless joins an elite band of scientists who have won two Nobel prizes. The other individuals are John Bardeen who won the Physics prize twice, Marie Curie, who won Physics and Chemistry, Linus Pauling who won Chemistry and Peace and Frederick Sanger who won the Chemistry prize twice.

“I’m absolutely stunned, I’m sitting here and I can hardly breathe,” Bertozzi said from California after the academy reached her by telephone with the news she had won.

She added that as part of her work, she and her team managed to visualize and understand cell surface structures known as glycans, leading to a new idea in cancer immune therapy.

The academy said the laureates’ discoveries had been used far beyond oncology, enabling products such as antimicrobials, herbicides, diagnostic tests, corrosion retardants and brightening agents.

Bertozzi works at Stanford University, Sharpless works at the Scripps Research institute, both in California, while Meldal is at the University of Copenhagen, Denmark.

Meldal told Reuters his legs and body started shaking with excitement when the Nobel committee called.

“It is not every day to have a Dane get the Nobel Prize,” he said, adding he had been recording a teaching video when he received the news and that he was very proud on behalf of his colleagues and team.

The third of the prizes unveiled over six consecutive weekdays, the chemistry Nobel follows those for medicine and physics announced earlier this week.

The 2021 chemistry award was won by German Benjamin List and Scottish-born David MacMillan for their work in creating new tools to build molecules, aiding in the development of new drugs as well as in areas such as plastics.

The prizes for achievements in science, literature and peace were established in the will of Swedish dynamite inventor and businessman Alfred Nobel, himself a chemist, and have been awarded since 1901. Economics was added later.

The prizes have been awarded every year with a few interruptions, primarily for the world wars, and made no break for the COVID-19 pandemic though much of the pageantry and events were put on hold or temporarily moved online.

(Reporting by Niklas Pollard, Simon Johnson and Johan Ahlander in Stockholm, and Ludwig Burger in Frankfurt; additional reporting by Terje Solsvik in Oslo, Anna Ringstrom in Stockholm and Marie Mannes in Gdansk; editing by Frank Jack Daniel)

Privacy Statement

Our Privacy Commitment

TV5 Network Inc. values and respects your privacy. We are committed to safeguarding your personal data in compliance with Republic Act No. 10173 or the Data Privacy Act of 2012 and its implementing rules and regulations.

We have developed a Privacy Policy that adopts and observes appropriate standards for personal data protection. While our Privacy Policy sets out the general principles governing the collection, use, and disclosure of our users’ personal information, our Privacy Commitment seeks to inform you more about TV5’s privacy practices.

Why do we collect your personal information (as applicable)?

We may collect and maintain basic information about you as site user of TV5 sites for the following purposes:

To deliver news and updates on current events, sports, esports and entertainment;
To share livestreams of news and sports events;
To understand our viewers’ needs and preferences;
To meet legal and regulatory requirements; and
To perform other processes or disclosures that are required to comply with pertinent laws, rules, or regulations.

Where do we get your personal information?

There are several ways we collect your personal information.

Information that you personally provided.

Most of the personal information we have are those that you have provided us when you:
- Register to our programs or services;
- Inquired, filed a complaint or requested for our services;
- Took part in our research and surveys; and/or
- Became our Partner, Vendor, Contractor or Supplier.

Information we collect during your engagement with us

We also collect information as you use our products and services, like:
- Viewing our websites;
- Activities that are being tracked by our website cookies;
- Calling our hotline;
- Using our apps, websites, and self-service channels and portals; and/or
- Joining our promos, prize raffles, or rewards and loyalty programs.

Information we collect from other sources

Other means of collection of information may be through:
- Our market research initiatives;
- When you visit and use our websites and mobile application; and
- Subsidiaries, affiliates, and third-party business partners to whom you have given consent to share your information to us.

When do we disclose personal information?

There may be instances when we are required to share the information you provided us. In such cases, we ensure that your personal information will be disclosed on a confidential manner, through secure channels and in compliance with the Data Privacy Act and other privacy laws.

We will never share, rent, or sell your personal information to third parties outside of TV5 except in special cases where you have given consent, and in cases described in our privacy policy.

In some instances, we may be required to disclose your personal information to our agents, subsidiaries, affiliates, business partners and other third-party agencies and service providers as part of our regular business operations and for the provision of our programs and services. This means we might share your information with our service providers, contractors, and professional advisers who help us provide our services.

How we protect your personal information

The integrity, confidentiality, and security of your information is important to us. We have implemented technical, organizational, and physical security measures that are designed to protect your information from unauthorized or fraudulent access, alteration, disclosure, misuse, and other unlawful activities.

We also put in effect the following safeguards:

We keep and protect your information using a secured server behind a firewall, encryption and security controls;
We keep your information only for as long as it is necessary for us to (a) provide the products and services that you avail from us, (b) for our legitimate business purposes, (c) to comply with pertinent laws, and (d) for special cases that will require the exercise or defense of legal claims;
We limit the access to your information only to qualified and authorized personnel who are trained to handle your information with strict confidentiality;
We undergo regular audits and rigorous testing of our infrastructure’s security protocols to ensure your data is always protected;
We promptly notify you and the National Privacy Commission when sensitive personal information that may, under the circumstances, be used to enable identity fraud are reasonably believed to have been acquired by an unauthorized person; and
We let you update your information securely to keep our records accurate.

TV5 will not collect, use, or disclose your personal information for any purpose other than the purpose that you may have given your consent for.

What are your choices?

We make sure that we have your consent to continue to collect, use, and disclose your personal information for the purposes that we have identified. We want you to know that you may object or withdraw your consent and/or edit your consent preferences at any time.

If you wish to have access to the personal information in our custody or if you think that the personal information you provided is incomplete, or otherwise inaccurate, you may get in touch with our Data Protection Officer through the contact details provided below. In some instances, we may request for supporting documents or proof before we effect requested changes.

Data Protection Officer
TV5 Network Inc.
Reliance corner Sheridan Streets
Mandaluyong City
tv5dataprivacy@tv5.com.ph

What happens when there are changes in our Policy?

From time to time, we may update our privacy policy and practices to comply with changes in applicable laws and regulatory requirements, adapt to new technologies and protocols, and align with the best practices of the industry.

You will be provided notices if the changes are significant and, if we are required by law, we will obtain your updated consent.